Human cathepsin S gene (CTSS) promoter −25G/A polymorphism
نویسندگان
چکیده
منابع مشابه
Human cathepsin S: chromosomal localization, gene structure, and tissue distribution.
The human lysosomal cysteine proteinases, cathepsins H, L, and B, have been mapped to chromosomes 15, 9, and 8, respectively, and the genomic structures of cathepsins L and B have been determined. We report here the chromosomal localization and partial gene structure for a recently sequenced human cysteine proteinase, cathepsin S. A 20-kilobase pair genomic clone of the human cathepsin S gene w...
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Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system is believed to have a T cell-mediated autoimmune etiology. The cytotoxic T lymphocyte antigen 4 (CTLA-4) gene is a strong candidate for the involvement in autoimmune diseases. To examine the genetic association of the CTLA-4 gene locus with MS, in a case-control design, we analyzed (-318 C/T) sin...
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15 صفحه اولCathepsin S is aberrantly overexpressed in human hepatocellular carcinoma.
Several lysosomal cathepsins have been implicated in a number of diseases, from arthritis to cancer. A recent member of the cathepsin family, cathepsin S (Cat S) has been associated with several types of cancer in humans. However, to date, no report has linked Cat S to human hepatocellular carcinoma (HCC). Here, we investigated the expression of Cat S in human normal and HCC livers using immuno...
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ژورنال
عنوان ژورنال: Journal of Human Genetics
سال: 2000
ISSN: 1434-5161,1435-232X
DOI: 10.1007/s100380050019